Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.1K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.1K
Multi-pass Transmembrane Proteins and β-barrels01:09

Multi-pass Transmembrane Proteins and β-barrels

6.0K
In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
6.0K
Protein Networks02:26

Protein Networks

4.3K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.3K
Protein Networks02:26

Protein Networks

2.6K
2.6K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.4K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global molecular landscape of early MASLD progression in human obesity.

eLife·2026
Same author

Metabolomics in cardiovascular diseases: from prevention strategies to domain-specific applications.

Expert review of proteomics·2025
Same author

Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.

Communications medicine·2025
Same author

Combined circulating microRNA and peptide biomarkers for prognostication in heart failure.

Cardiovascular research·2025
Same author

Context specific ubiquitin modification of ribosomes regulates translation under oxidative stress.

bioRxiv : the preprint server for biology·2025
Same author

Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes.

Journal of the American Heart Association·2024

Related Experiment Video

Updated: Nov 9, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.1K

multiSLIDE is a web server for exploring connected elements of biological pathways in multi-omics data.

Soumita Ghosh1, Abhik Datta2,3, Hyungwon Choi4

  • 1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Nature Communications
|April 17, 2021
PubMed
Summary
This summary is machine-generated.

Interpreting complex multi-omics data is challenging. multiSLIDE is a new web tool that visualizes interconnected molecular features across different omics datasets, simplifying data analysis and interpretation.

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

15.7K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.5K

Related Experiment Videos

Last Updated: Nov 9, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.1K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

15.7K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.5K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Data Visualization

Background:

  • Quantitative multi-omics data present interpretation and visualization challenges due to large volumes, complex feature interactions, and data heterogeneity.
  • Existing tools often struggle to simultaneously visualize interconnected features from diverse omics platforms.

Purpose of the Study:

  • To introduce multiSLIDE, an interactive web-based tool designed for simultaneous visualization of interconnected molecular features within multi-omics datasets.
  • To provide a user-friendly platform for exploring complex biological data by integrating information from various omics sources.

Main Methods:

  • multiSLIDE utilizes keyword searches (pathways, genes) to visualize biologically connected molecular features.
  • The tool offers real-time interactive functionalities including querying, rearranging, filtering, and clustering of data within a web browser.
  • It supports diverse omics types and allows for customizable visualizations and incorporation of custom inter-molecular relationships.

Main Results:

  • Demonstrated the versatility of multiSLIDE through three distinct examples across various multi-omics datasets.
  • Successfully visualized established links between molecules from different omics data types.
  • Enabled users to integrate custom inter-molecular relationship information into the visualization process.

Conclusions:

  • multiSLIDE effectively addresses the challenges of multi-omics data interpretation and visualization.
  • The tool enhances biological discovery by facilitating the simultaneous exploration of interconnected molecular features.
  • multiSLIDE is available as both an online and stand-alone application, promoting accessibility for researchers.