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Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy
Namita Gwasikoti1, Kapil Bhalla2, Jaya Shankar Kaushik1
1Department of Pediatrics, Pt. BD Sharma PGIMS, Rohtak, Haryana.
Insights
Children with cerebral palsy (CP) often have vitamin D deficiency, low bone mineral density, and reduced insulin-like growth factor 1 (IGF-1) levels, indicating potential growth issues.
Area of Science:
- Pediatrics
- Endocrinology
- Orthopedics
Background:
- Cerebral palsy (CP) affects motor function and can impact overall health.
- Nutritional deficiencies and growth abnormalities are common concerns in children with CP.
Purpose of the Study:
- To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density (BMD), and insulin-like growth factor 1 (IGF-1) levels in children with CP versus healthy controls.
- To investigate potential differences between CP with and without epilepsy.
Main Methods:
- A cross-sectional study included 90 children aged 1-8 years, divided into three groups: CP with epilepsy, CP without epilepsy, and healthy controls (30 per group).
- Measurements included bone mineral density (BMD), serum 25-OHD levels, and serum IGF-1 levels.
Main Results:
- Children with CP (both with and without epilepsy) showed significantly lower BMD z-scores compared to controls.
- Serum 25-OHD levels and IGF-1 levels were significantly lower in children with CP compared to healthy controls.
- These differences were statistically significant (P<0.01).
Conclusions:
- Children with CP, with or without epilepsy, are at higher risk for vitamin D deficiency.
- Low bone mineral density and suppressed growth hormone axis indicated by low IGF-1 levels are prevalent in children with CP.
- These findings highlight the need for monitoring and intervention for bone health and growth in children with CP.
Objectives:
To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.
Methods:
A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.
Results:
z-scores of BMD [-1.80 (1.03), -2.12 (0.85) vs -1.40 (0.90); P<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL; P<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL; P<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.
Conclusions:
Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.
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