Nitrosamine formation from the reaction of methamphetamine with gaseous nitrous acid

Methamphetamine is the most commonly seized amphetamine-type stimulant (ATS) worldwide. Chemical residues associated with the use or manufacture of methamphetamine can persist in the air and surfaces in a property for over 5 years and potentially pose risks to the health and safety of the public. When a house is tested for contamination, the test focuses on the presence of surface methamphetamine residue; however, other hazardous chemicals may also be present, including methamphetamine precursors and reaction products. As little has been reported about the ageing of the methamphetamine inside dwellings, there is currently large uncertainty regarding its fate and/or degradation products in such environments. If the indoor reactivity of methamphetamine is similar to that of nicotine-derived third-hand smoke, the production of a carcinogenic nitrosamine is an expected result. Thus, this proof-of-concept study investigated the reaction of methamphetamine with the common gaseous indoor oxidant nitrous acid (HONO) and monitored the fate of the resulting reaction products in simulated laboratory experiments to further understand the potential health risks associated with contaminated properties. Surface methamphetamine residue was observed to decrease with an exponential decay with an upper limit of 2.38 ± 0.5 × 10^-3  min^-1 upon exposure to HONO gas (5.7 ppmv, 0.25 L min^-1 ). N-nitrosomethamphetamine (NMA), a suspected human mutagen and carcinogen, was detected to have a steady-state formation over the sampling time frame, with a surface area concentration of 0.87 μg/100 cm² , suggesting that the risks to public health for properties contaminated with methamphetamine may be currently underestimated.