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Adjunct therapy with probiotics for chronic urticaria in children: randomised placebo-controlled trial
Xiao-Dong Bi1, Bao-Zhen Lu2, Xin-Xin Pan2
1Department of Dermatology, Nanyang First People's Hospital, Nanyang, 411300, Henan, China. gybxd2004@163.com.
Insights
This study found that Yimingjia® probiotic formula, when used alongside standard treatment, effectively reduced chronic urticaria symptoms in children after four weeks. The probiotic supplement demonstrated safety and improved overall response rates compared to placebo.
Area of Science:
- Pediatric Dermatology
- Gastroenterology
- Immunology
Background:
- Chronic urticaria is a prevalent skin condition characterized by recurrent wheals and angioedema.
- Gut microbiota alterations are increasingly linked to immune dysregulation, potentially causing chronic urticaria.
Purpose of the Study:
- To assess the efficacy of Yimingjia® probiotic formula as an adjunctive therapy for pediatric chronic urticaria.
Main Methods:
- A randomized controlled trial involving 206 children diagnosed with chronic urticaria.
- Participants received either desloratadine plus Yimingjia® (treatment group) or desloratadine plus placebo (control group).
- Clinical efficacy was evaluated at 1, 2, and 4 weeks.
Main Results:
- Significant reductions in wheal size and attack frequency were observed in the Yimingjia® group at 4 weeks (p=0.049 and p=0.03).
- The overall response rate was significantly higher in the treatment group (80.8%) compared to the placebo group (62.5%) (p=0.04).
- No significant differences in symptom scores were noted at weeks 1 and 2.
Conclusions:
- Adjunct therapy with Yimingjia® probiotic formula is safe and effective for treating chronic urticaria in children within 4 weeks.
- The findings support the use of probiotics to manage pediatric chronic urticaria.
- The study is registered under NCT03328897.
Backgrounds:
Chronic urticaria is a common disorder of the skin, characterised by recurrent skin wheals and angioedema. Recent reports have shown that altered diversity and composition of the gut microbiota may lead to imbalances in immune regulation, a causal factor in the occurrence of chronic urticaria.
Objective:
This study aimed to evaluate the efficacy of the Yimingjia® probiotic formula in the adjuvant treatment of chronic urticaria in children.
Methods:
We enrolled 206 children with confirmed diagnoses of chronic urticaria and randomly assigned them to the treatment (n = 104) or placebo group (n = 102). The children in each group were treated with desloratadine dry suspension, and those in the treatment group also received Yimingjia®. Clinical efficacy was evaluated at 1, 2 and 4 weeks.
Results:
Clinical symptom scores did not differ significantly at weeks 1 and 2 (p > 0.05), but at 4 weeks, wheal size and attack frequency were significantly reduced in the treatment group (p = 0.049 and 0.03, respectively). The overall response rate (significant improvement + complete response) significantly differed between the treatment (80.8%) and placebo groups (62.5%) (χ2 = 4.20, p = 0.04).
Conclusion:
Adjunct therapy with Yimingjia® was safe and effective at 4 weeks in the treatment of chronic urticaria in children. The study was registered under trial number NCT03328897.
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