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Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Nov 8, 2025

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Engineering Strategies for Allogeneic Solid Tissue Acceptance.

Ana Rita Sousa¹, João F Mano¹, Mariana B Oliveira¹

¹Department of Chemistry, CICECO - Aveiro Institute of Materials, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

Trends in Molecular Medicine

|April 18, 2021

Summary

This summary is machine-generated.

Preventing solid organ transplant rejection is crucial. This review explores cellular therapies and bioinspired engineering strategies to induce tolerance and avoid non-targeted immunosuppression side effects.

Keywords:

allogeneic transplantation bioengineering acceptance-inducing strategies cellular/acellular therapeutics tissue engineering

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Area of Science:

Immunology
Transplantation Biology
Biomedical Engineering

Background:

Allogeneic transplantation relies on preventing graft rejection.
Current non-targeted immunosuppressants cause severe morbidities and late graft loss.
Understanding rejection mechanisms is key for advancing transplantation.

Purpose of the Study:

To analyze the biology of allogeneic rejection and self-tolerance.
To review cellular-based therapeutics for graft suppression and tolerance.
To address bioinspired engineering strategies for preventing rejection.

Main Methods:

Literature review of allogeneic rejection mechanisms.
Analysis of cellular therapy mechanisms driving suppression and tolerance.
Examination of bioinspired engineering strategies using cells and biomaterials.

Main Results:

Non-targeted immunosuppressants have significant drawbacks.
Cellular therapies offer potential for targeted suppression and tolerance.
Bioinspired engineering presents novel strategies for graft protection.

Conclusions:

Advances in transplantation require deeper understanding of rejection and tolerance.
Cellular therapies and bioinspired engineering hold promise for improved outcomes.
Developing targeted strategies can mitigate risks associated with current immunosuppression.