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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Right Heart Phenotype in Heart Failure With Preserved Ejection Fraction
Marco Guazzi1,2, Robert Naeije3
1Department of Biological Sciences, University of Milano, Italy (M.G.).
Circulation. Heart Failure
|April 19, 2021
Summary
Heart failure with preserved ejection fraction (HFpEF) lacks effective treatments due to its complexity. Right ventricular dysfunction is a key factor in HFpEF progression and poor outcomes, suggesting new therapeutic targets.
Area of Science:
- Cardiology
- Heart Failure Research
- Right Ventricle Physiology
Background:
- Heart failure with preserved ejection fraction (HFpEF) presents a significant health burden with limited treatment options.
- The mechanistic heterogeneity of HFpEF hinders therapeutic development.
- Advancements in diagnostics and imaging are crucial for understanding HFpEF.
Purpose of the Study:
- To review the current understanding of right ventricular dysfunction in HFpEF.
- To explore the role of right ventricular dysfunction in HFpEF progression and patient outcomes.
- To discuss potential new therapeutic strategies targeting the right ventricle in HFpEF.
Main Methods:
- Review of current literature on HFpEF pathophysiology.
- Analysis of advancements in imaging techniques and pressure signaling.
- Examination of right heart phenotypes and their impact on HFpEF.
Main Results:
- Right ventricular dysfunction is identified as a mediator of HFpEF progression.
- Right ventricular dysfunction is a major independent determinant of poor outcomes in HFpEF.
- Phenomapping and advanced diagnostics are key for future progress.
Conclusions:
- Targeting right ventricular function and geometry offers promising therapeutic avenues for HFpEF.
- Understanding right ventricular dysfunction is critical for improving HFpEF management.
- Personalized treatment strategies based on HFpEF phenotypes are needed.
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