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Related Concept Videos

Spinal Nerves: Plexus I01:22

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Related Experiment Video

Updated: Nov 8, 2025

Traumatic Peripheral Nerve Injury in Mice
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Peripheral Nerve Basic Science Research-What Is Important for Hand Surgeons to Know?

Sara Saffari1, Tiam M Saffari1, Amy M Moore2

  • 1Division of Hand and Microvascular Surgery, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN; Department of Plastic, Reconstructive, and Hand Surgery, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.

The Journal of Hand Surgery
|April 19, 2021
PubMed
Summary

Basic science research on peripheral nerve regeneration using animal models faces a translational gap. Understanding study design and outcome measures is crucial for applying these findings to clinical practice in hand surgery.

Keywords:
Basic sciencenerve regenerationoutcome measureperipheral nerve injury

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Hand Surgery Research

Background:

  • Peripheral nerve injury and regeneration are key research areas.
  • Current basic science research primarily uses animal models.
  • A significant gap exists between basic science findings and clinical application.

Purpose of the Study:

  • To review the importance of study design in peripheral nerve regeneration research.
  • To highlight the significance of outcome measures in basic science studies.
  • To aid hand surgeons in understanding basic science research for clinical translation.

Main Methods:

  • Literature review of basic science research on peripheral nerve regeneration.
  • Analysis of study design elements impacting translational potential.
  • Evaluation of outcome measures used in animal models.

Main Results:

  • Study design, outcome selection, and timing significantly influence peripheral nerve regeneration research.
  • Inconsistent methodologies hinder direct clinical translation.
  • Standardized approaches are needed to bridge the research-clinical gap.

Conclusions:

  • Careful consideration of study design and outcome measures is essential for successful peripheral nerve regeneration research.
  • Improved understanding of basic science research methodologies can facilitate clinical translation.
  • This overview aims to enhance hand surgeons' interpretation of preclinical data for patient benefit.