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Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

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Advances in management of end stage liver disease in children

Aradhana Aneja1, Elizabeth Scott2, Rohit Kohli3

  • 1Classified Specialist (Pediatrics) & Pediatric Gastroenterologist, Army Hospital (R&R), New Delhi, India.

Medical Journal, Armed Forces India
|April 19, 2021
PubMed

Insights

End-stage liver disease (ESLD) in children presents unique challenges. This review highlights advances in managing paediatric ESLD, emphasizing nutritional support for improved outcomes.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Clinical Management of Chronic Diseases

Background:

  • End-stage liver disease (ESLD) in children is a complex pediatric management challenge.
  • Pediatric ESLD has distinct etiologies and natural histories compared to adults, varying with age at presentation.
  • Children with ESLD are particularly susceptible to malnutrition, frailty, and developmental delays.

Purpose of the Study:

  • To provide a concise review of end-stage liver disease (ESLD) in children.
  • To highlight recent advances in the management of pediatric ESLD.
  • To underscore the critical role of nutritional support in the clinical course and survival of these patients.

Main Methods:

  • Literature review focusing on pediatric ESLD.
  • Analysis of current management strategies for pediatric ESLD.
  • Examination of recent advancements in treatment and supportive care.

Main Results:

  • Nutritional support is a cornerstone of management, significantly impacting outcomes before and after transplantation.
  • Complications such as ascites, portal hypertension, spontaneous bacterial peritonitis, and encephalopathy present unique pediatric challenges.
  • Recent advances offer improved therapeutic options and supportive care protocols.

Conclusions:

  • Effective management of pediatric ESLD requires addressing its unique age-dependent characteristics and vulnerabilities.
  • Aggressive nutritional support is vital for improving the clinical trajectory and survival rates in children with ESLD.
  • Continued research and implementation of recent advances are crucial for optimizing the care of children with end-stage liver disease.

Keywords:
Liver failureLiver injuryNutritionPediatricsTransplant

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