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Effects of cholecystokinin-related peptides on self-stimulation behaviour in rats
M Balázs1, H Schwarzberg, B Penke
1Department of Pathophysiology, University Medical School, Szeged, Hungary.
Neuropeptides
|April 1, 1988
Abstract:
The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE), its N-terminal tripeptide (CCK-2-4-SE) and its C-terminal tetrapeptide (CCK-5-8) were investigated on hypothalamic self-stimulation in rats. CCK-8-SE and CCK-5-8 in 400 pmole doses inhibited self-stimulation behaviour, while CCK-2-4-SE was ineffective. In 80 pmole doses the peptides showed no effect. It is suggested that CCK-5-8 itself influences self-stimulation behaviour.