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Study Protocol: The Heart and Brain Study.

Sana Suri1,2, Daniel Bulte3, Scott T Chiesa4

  • 1Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.

Frontiers in Physiology
|April 19, 2021
PubMed
Summary
This summary is machine-generated.

The Heart and Brain Study investigates how midlife vascular risk impacts brain health and cognitive decline. Findings will help identify individuals for interventions to prevent or delay dementia.

Keywords:
MRIageingcerebrovascular reactivitycognitiondementia preventionheart-brainlongitudinal cohortultrasound

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Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Gerontology

Background:

  • The link between cardiovascular health and brain function is well-established, with vascular risk factors increasing dementia risk.
  • Mechanisms connecting heart health to brain health, particularly cerebrovascular reactivity (CVR), are under investigation.
  • Impaired vascular phenotypes and CVR are implicated in cognitive decline.

Purpose of the Study:

  • To examine the long-term effects of midlife vascular risk on cerebrovascular health and cognitive decline.
  • To investigate the relationship between vascular phenotypes, CVR, and brain structure and function.
  • To identify optimal windows for vascular risk management to delay cognitive decline.

Main Methods:

  • Utilizing data from the Whitehall II Imaging cohort, including 3T brain MRI, neuropsychological tests, and vascular assessments.
  • Conducting ultrasound of the aorta and carotid arteries, blood pressure measurements, and advanced MRI to assess CVR, cerebral blood flow, and lesions.
  • Analyzing 30-year trajectories of vascular risk from midlife (40-70 years) to older age.

Main Results:

  • This study is designed to generate a comprehensive dataset on the heart-brain association.
  • It will provide insights into physiological processes linking vascular health to cognitive function.
  • The research aims to establish how vascular risk throughout life influences brain aging.

Conclusions:

  • The Heart and Brain Study will yield a detailed dataset for understanding the longitudinal determinants of the heart-brain link.
  • Findings will inform strategies for early identification of individuals at risk for cognitive decline.
  • The study aims to guide interventions for preventing or delaying dementia by optimizing vascular risk management.