Related Experiment Video
Updated: Nov 8, 2025
08:51
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
1.7K
Subtypes identification on heart failure with preserved ejection fraction via network enhancement fusion using
Yongqing Wu1, Huihui Wang1, Zhi Li2
1Division of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
Computational and Structural Biotechnology Journal
|April 19, 2021
Summary
Identifying heart failure with preserved ejection fraction (HFpEF) subtypes using multi-omics data improves prognosis. A novel network fusion method identified high-risk and low-risk HFpEF patient groups with distinct survival rates.
Area of Science:
- Cardiovascular Medicine
- Bioinformatics
- Genomics
Background:
- Heart failure with preserved ejection fraction (HFpEF) presents significant clinical heterogeneity, complicating effective treatment and prognosis.
- Understanding the molecular underpinnings of HFpEF is crucial for developing targeted therapies.
Purpose of the Study:
- To identify distinct clinical subtypes of HFpEF by integrating multi-omics data.
- To develop a novel computational framework for robust subtype discovery in complex diseases.
Main Methods:
- Integration of mRNA, DNA methylation, and microRNA expression data from HFpEF patients.
- Application of a novel network enhancement followed by similarity network fusion (ne-SNF) for data integration.
- Utilized spectral clustering to identify patient subgroups.
Main Results:
- The ne-SNF method successfully identified two distinct HFpEF patient subtypes with significantly different survival outcomes.
- A high-risk group (16.8% of patients) exhibited a 5-year mortality rate of 63.3%, compared to 33.0% in the low-risk group (83.2%).
- Identified differentially expressed genes, methylation patterns, and miRNAs associated with these subtypes, enriched in HFpEF-related pathways.
Conclusions:
- The ne-SNF approach provides a powerful pipeline for multi-omics data integration and subtype discovery in HFpEF.
- Subtyping HFpEF patients can lead to more precise prognostic assessments and personalized treatment strategies.
Related Concept Videos
01:30Heart Failure IV: Classification and Diagnostic Evaluation
111
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
111
01:29Heart Failure II: Pathophysiology
154
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
154
01:17Pathophysiology of Heart Failure
2.1K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.1K
01:27Heart Failure I: Introduction
189
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
189
01:25Cardiomyopathy I: Introduction and Classification
180
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
180
01:26Heart Failure III: Clinical Manifestations
128
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
128