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BioMEMS and Cellular Biology: Perspectives and Applications
Published on: October 1, 2007
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A review of BioFET's basic principles and materials for biomedical applications
Daeun Sung1, Jahyun Koo1,2
1School of Biomedical Engineering, Korea University, Seoul, 02841 Republic of Korea.
Biomedical Engineering Letters
|April 19, 2021
Summary
Field-effect transistor (FET)-based biosensors (BioFETs) offer versatile diagnostic capabilities. This review covers BioFET materials, probes, design principles, and applications for early disease detection and monitoring.
Area of Science:
- Biomolecular sensor technology
- Field-effect transistor (FET) biosensors (BioFETs)
- Nanomaterials for biosensing
Background:
- Increasing demand for early disease diagnosis and prognosis.
- Field-effect transistor (FET)-based biosensors (BioFETs) show promise due to versatile operating characteristics.
- Need for comprehensive review of BioFET components and applications.
Purpose of the Study:
- To provide an overall review of BioFETs, focusing on transducing materials and probes.
- To discuss key design elements, including electrical properties, Debye length, and fabrication.
- To explore diverse applications of BioFETs in antigen sensing, biomarker detection, and drug effect monitoring.
Main Methods:
- Review of fundamental BioFET principles.
- Classification and analysis of transducing materials (graphene, carbon nanotube, silicon, MOF) and probes (antibodies, enzymes, aptamers).
- Discussion of design considerations, fabrication processes, and performance metrics (sensitivity, selectivity, limit of detection).
Main Results:
- Detailed examination of various BioFET structures and material properties.
- Examples illustrating the performance of different BioFET configurations.
- Overview of novel materials and processes for enhanced biosensing capabilities.
Conclusions:
- BioFETs are highly effective for diverse applications including antigen and biomarker sensing.
- Future development should focus on overcoming key challenges and exploring innovative materials.
- Continued advancement in BioFET technology is crucial for improving disease diagnosis and patient prognosis.
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