Burden and prevalence of risk factors for severe COVID-19 in the ageing European population - a SHARE-based analysis

Linda Juel Ahrenfeldt1, Camilla Riis Nielsen1,2, Sören Möller3,4

  • 1Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000 Odense, Denmark.

Insights

Over 75% of Europeans aged 50+ have risk factors for severe COVID-19, with many having multiple conditions. This highlights the need for targeted public health strategies to protect vulnerable populations from the pandemic.

Area of Science:

  • Public Health
  • Epidemiology
  • Gerontology

Background:

  • International health authorities identify older adults (65+) and those with comorbidities as high-risk for severe COVID-19.
  • Prevalence data for these risk factors are lacking in many European countries.
  • Understanding risk factor distribution is crucial for pandemic mitigation strategies.

Purpose of the Study:

  • To describe the distribution of COVID-19 risk factors across Europe.
  • To identify the prevalence of underlying medical conditions associated with severe COVID-19.
  • To inform public health authorities about vulnerable subpopulations.

Main Methods:

  • Utilized data from 73,274 Europeans aged 50+ from the 2017 Survey of Health, Ageing and Retirement in Europe (SHARE).
  • Assessed prevalence of risk factors including hypertension, chronic lung disease, cardiovascular disease, cancer, diabetes, and obesity.
  • Estimated disease burden using Eurostat population data.

Main Results:

  • 75.3% of the study population had at least one risk factor for severe COVID-19.
  • 45.9% had at least two risk factors, and 21.2% had at least three risk factors.
  • Prevalence of individual conditions ranged from 4.5% (cancer) to 41.4% (hypertension); regional variation in multiple risk factors was observed (18.9% in Northern Europe to 24.6% in Eastern Europe).

Conclusions:

  • A significant majority of older Europeans possess risk factors for severe COVID-19.
  • Identifying individuals with multiple risk factors is essential for targeted pandemic response.
  • This information can guide the development of effective mitigation strategies to protect vulnerable groups.
Abstract

Related Concept Videos

Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
46
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
59
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
919
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
55