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MR-Guided Radiotherapy for Liver Malignancies.

Luca Boldrini1, Stefanie Corradini2, Cihan Gani3

  • 1Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Roma, Italy.

Frontiers in Oncology
|April 19, 2021
PubMed
Summary

MR guided radiotherapy (MRgRT) offers improved visualization for liver cancer treatment, potentially enhancing outcomes and reducing toxicity. This review explores MRgRT

Keywords:
image guided radiation therapyliver cancerliver malignanciesmagnetic resonance guided radiotherapyonline adaptive radiation therapystereotactic body radiation therapy

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Area of Science:

  • Oncology
  • Radiotherapy
  • Medical Imaging

Background:

  • Magnetic Resonance guided radiotherapy (MRgRT) is an emerging technology in cancer treatment.
  • It allows for real-time visualization of tumors and surrounding tissues during radiation delivery.
  • This capability is particularly relevant for mobile tumors like those found in the liver.

Purpose of the Study:

  • To review the current evidence on the application of MRgRT for liver malignancies.
  • To discuss the potential clinical benefits of MRgRT in treating liver cancers.
  • To identify and analyze the challenges and limitations associated with MRgRT in this context.

Main Methods:

  • Systematic literature review of studies investigating MRgRT for liver tumors.
  • Analysis of data regarding treatment efficacy, toxicity, and technical aspects.
  • Discussion of adaptive radiotherapy and motion management strategies within MRgRT.

Main Results:

  • MRgRT enables enhanced visualization of liver tumors, improving treatment accuracy.
  • Online adaptive radiotherapy and motion management are key features for efficient delivery.
  • Potential for improved treatment response and reduced side effects in liver cancer patients.

Conclusions:

  • MRgRT shows significant promise for liver malignancies due to superior imaging and adaptive capabilities.
  • Further research and technological refinement are needed to overcome current limitations.
  • MRgRT may lead to better clinical outcomes and reduced toxicity in liver cancer management.