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Recurrent respiratory papillomatosis: A 2020 perspective.
Jacob J Benedict1, Craig S Derkay2
1Department of Otolaryngology - Head and Neck Surgery, Eastern Virginia Medical School Sentara Norfolk General Hospital Norfolk Virginia USA.
Recurrent respiratory papillomatosis (RRP) incidence is declining due to human papillomavirus (HPV) vaccination. New treatments like Bevacizumab show promise for managing RRP.
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Area of Science:
- Otolaryngology
- Oncology
- Vaccinology
Background:
- Recurrent respiratory papillomatosis (RRP) is a rare, challenging benign airway neoplasm.
- Disease incidence is shifting due to human papillomavirus (HPV) vaccination and prevention strategies.
Purpose of the Study:
- To review the epidemiology, prevention, and treatment of RRP.
- To highlight the impact of HPV vaccination on RRP incidence.
- To discuss emerging treatment modalities for RRP.
Main Methods:
- PubMed database search using "recurrent respiratory papillomatosis" MeSH terms.
- Review of titles and abstracts for relevance, with full-text review of select articles.
- Synthesis of data to provide an update on RRP management.
Main Results:
- Significant decrease in RRP incidence observed with increased HPV vaccine (9-valent and quadrivalent) utilization.
- Preliminary data from the US indicates a similar trend of decreased RRP incidence post-vaccination.
- The HPV vaccine shows potential as a treatment in addition to prevention.
- Bevacizumab (Avastin) demonstrates promise as a systemic RRP treatment.
- COVID-19 pandemic impacted perioperative management of RRP.
Conclusions:
- RRP incidence continues to decline following HPV vaccination implementation.
- Advancements in medical management, including Bevacizumab, offer promising additional options for RRP treatment.