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Updated: Nov 8, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Climate-based dengue model in Semarang, Indonesia: Predictions and descriptive analysis
Nuning Nuraini1,2, Ilham Saiful Fauzi1, Muhammad Fakhruddin3,1
1Department of Mathematics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia.
This study developed a climate-based mathematical model to forecast dengue incidence by linking meteorological factors to disease transmission. The model accurately predicts dengue outbreaks, aiding public health efforts against this vector-borne disease.
Area of Science:
- Epidemiology
- Mathematical Modeling
- Environmental Science
Background:
- Dengue is a rapidly spreading vector-borne disease posing significant health risks in tropical and subtropical regions.
- Climate is strongly correlated with both the abundance of dengue vectors and disease incidence.
- Developing climate-based mathematical models for dengue transmission is crucial due to these associations.
Purpose of the Study:
- To construct a host-vector model simulating dengue transmission dynamics.
- To integrate meteorological factors into the disease infection model.
- To forecast dengue incidence using climate variables.
Main Methods:
- A host-vector model was developed to simulate transmission dynamics.
- The infection rate was optimized daily using climate data and autoregressive distributed lag (ARDL) models.
- The optimized infection rate was modeled as a function of climate variables.
Main Results:
- Daily climate data can be used to extend the infection parameter for forecasting dengue incidence.
- The model demonstrated accurate predictions across varying prediction window lengths.
- Specific climate associations were identified: reversed slide-shaped for humidity, reversed U-shaped for temperature and precipitation, with optimal temperature ranges and humidity/precipitation thresholds.
Conclusions:
- Identifying climate-dengue associations is vital for mitigating dengue risk.
- This approach can enhance public health systems.
- It offers a strategy to reduce the growing burden of dengue.
Related Concept Videos
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