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Cardiac Complications and Pertaining Mortality Rate in COVID-19 Patients; a Systematic Review and Meta-Analysis

Amirmohammad Toloui1, Donya Moshrefiaraghi1, Arian Madani Neishaboori1

  • 1Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Archives of Academic Emergency Medicine
|April 19, 2021
PubMed

Insights

COVID-19 patients frequently experience cardiac complications like acute cardiac injury and abnormal troponin levels. These conditions significantly increase mortality risk, highlighting the need for routine cardiac assessments.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiac complications are significant concerns for COVID-19 patients.
  • Understanding the prevalence and impact of these complications is crucial for patient recovery and management.

Purpose of the Study:

  • To investigate the prevalence of cardiac complications in COVID-19 patients.
  • To determine the association between cardiac complications and mortality rates in COVID-19.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, Embase, Scopus, Web of Science) and preprint servers.
  • Articles published from 2019 to April 2020 reporting cardiac complications in confirmed COVID-19 cases were included.

Main Results:

  • Forty articles involving 853 records indicated high prevalence of acute cardiac injury (19.46%), heart failure (19.07%), and cardiac arrest (3.44%).
  • Abnormal serum troponin levels were found in 22.86% of patients.
  • Acute cardiac injury and abnormal troponin levels were associated with significantly increased odds of mortality (14.24 and 19.03 times higher, respectively).

Conclusions:

  • Acute cardiac injury and elevated troponin levels are common in COVID-19 patients.
  • Cardiac complications are linked to a substantially higher mortality risk.
  • Routine troponin screenings and cardiac evaluations are recommended for COVID-19 patients.
Abstract

Keywords:
COVID-19Cardiovascular SystemHeart InjuriesHospital Mortality

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