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Published on: September 13, 2020
Contemporary treatment of May-Thurner Syndrome
Arash Fereydooni1, Jordan R Stern2
1Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA, USA.
Insights
May-Thurner Syndrome, caused by left iliac vein compression, can lead to leg swelling or deep vein thrombosis. Iliocaval stenting is a standard treatment with good outcomes.
Area of Science:
- Vascular Surgery
- Diagnostic Imaging
- Venous Disease Management
Background:
- May-Thurner Syndrome arises from left common iliac vein compression by the right common iliac artery.
- This compression can cause venous outflow obstruction, leading to unilateral leg swelling or deep vein thrombosis.
Purpose of the Study:
- To review the pathophysiology of May-Thurner Syndrome.
- To discuss diagnostic modalities and treatment options for May-Thurner Syndrome.
Main Methods:
- Review of existing literature on May-Thurner Syndrome.
- Analysis of diagnostic techniques including ultrasound, CT venography, MR venography, and intravascular ultrasound.
- Evaluation of treatment strategies, focusing on iliac vein stenting.
Main Results:
- May-Thurner Syndrome diagnosis relies on clinical presentation and imaging.
- Venography with intravascular ultrasound is optimal for assessing iliac vein compression severity.
- Iliocaval stenting demonstrates promising patency rates and clinical outcomes for treatment.
Conclusions:
- Understanding May-Thurner Syndrome's pathophysiology is crucial for diagnosis and management.
- A combination of diagnostic tools aids in identifying and assessing the severity of venous compression.
- Iliocaval stenting is an effective, standard treatment for hemodynamically significant May-Thurner Syndrome.
Abstract:
Compression of the left common iliac vein by the overlying right common iliac artery is a benign anatomic abnormality in most individuals. However, in patients with significant vein compression, outflow obstruction and chronic intraluminal venous damage may lead to May-Thurner Syndrome. This syndrome commonly manifests as unilateral left leg swelling or acute iliofemoral deep venous thrombosis. In addition to clinical findings, diagnosis is made with ultrasound, computed tomography venography, or magnetic resonance venography. The extent of compression of the iliac vein is best determined by venography with intravascular ultrasound. Symptoms and hemodynamic significance of the compression guides the ideal treatment approach. Iliocaval stenting has become the standard treatment for this condition and has promising patency rates and clinical outcomes. This review paper provided an overview of pathophysiology, and utility and limitations of the existing diagnostic modalities and treatment options in the management of May-Thurner Syndrome.
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