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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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Self-Assembled Multivalent Ag-SR Coordination Polymers with Phosphatase-Like Activity.

Ying-Juan Cao¹, Mei-Xia Yao¹, Leonard J Prins²

¹Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing, College of Materials Science and Engineering, Huaqiao University, Xiamen, 361021, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|April 19, 2021

Summary

This summary is machine-generated.

We developed novel coordination polymers with phosphatase-like activity. These metal-organic materials efficiently catalyze RNA model compound transphosphorylation, with activity tunable by alkyl chain length.

Keywords:

Ag-SR coordination polymers Artificial phosphatases homogeneous catalysis self-assembly supramolecular chemistry

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Area of Science:

Coordination chemistry
Catalysis
Materials science

Background:

Coordination polymers offer tunable structures and catalytic properties.
Metal-ion interactions with thiols and macrocycles are key for material assembly.
Phosphatase-like activity is crucial for various biochemical processes.

Purpose of the Study:

To synthesize and characterize novel coordination polymers with phosphatase-like catalytic activity.
To investigate the role of metal ions (Ag+, Zn2+) and hydrophobic chains in catalytic performance.
To explore the transphosphorylation of an RNA-model compound using these materials.

Main Methods:

Self-assembly of coordination polymers using thiols with hydrophobic alkyl chains and 1,4,7-triazacyclononane (TACN) groups.
Sequential addition of silver (Ag+) and zinc (Zn2+) ions to form multivalent metal coordination polymers.
Assay of catalytic activity using a model RNA compound (2-hydroxypropyl-4-nitrophenyl phosphate, HPNPP).

Main Results:

Coordination polymers formed by Ag+ and Zn2+ exhibited high transphosphorylation catalytic activity.
Optimal activity was achieved with Ag+ forming the polymer backbone and Zn2+ complexing the TACN group.
Catalytic efficiency was modulated by altering the length of the hydrophobic alkyl chain.

Conclusions:

Novel coordination polymers display significant phosphatase-like catalytic activity.
The specific metal ion sequence (Ag+ then Zn2+) and hydrophobic chain length are critical for optimizing catalysis.
These findings open avenues for designing advanced catalytic materials for biochemical applications.