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Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...

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Related Experiment Video

Updated: Nov 8, 2025

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

Published on: August 18, 2022

Innovative method to achieve precise cryolysis

Sanjeev Gupta¹, Ravi Shankar Jangra², Ajinkya Vinayak Gujrathi¹

¹Department of Dermatology, Venereology and Leprology, Maharishi Markandeshwar Institute of Medical Sciences and Research, MMDU, Mullana , Ambala, Haryana, India.

Indian Journal of Dermatology, Venereology and Leprology

|April 19, 2021

Summary

No abstract available in PubMed .

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