Related Experiment Video
Updated: Nov 8, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Safety issues related to intravenous contrast agent use in magnetic resonance imaging
Skorn Ponrartana1,2, Michael M Moore3, Sherwin S Chan4,5
1Department of Radiology, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS# 81, Los Angeles, CA, 90064, USA. sponrartana@chla.usc.edu.
Abstract:
Gadolinium-based contrast agents (GBCAs) have been used to improve image quality of MRI examinations for decades and have an excellent overall safety record. However, there are well-documented risks associated with GBCAs and our understanding and management of these risks continue to evolve. The purpose of this review is to discuss the safety of GBCAs used in MRI in adult and pediatric populations. We focus particular attention on acute adverse reactions, nephrogenic systemic fibrosis and gadolinium deposition. We also discuss the non-GBCA MRI contrast agent ferumoxytol, which is increasing in use and has its own risk profile. Finally, we identify special populations at higher risk of harm from GBCA administration.
Related Concept Videos
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Magnetic Resonance Imaging
Imaging Studies for Cardiovascular System IV: CMRI
Imaging Studies III: Computed Tomography
Radiological Investigation I: X-ray and CT
Imaging Studies IV: Magnetic Resonance Imaging

