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Updated: Nov 8, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle
1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Braden.Manns@albertahealthservices.ca.
Knowledge translation bridges the evidence to practice gap in healthcare. The knowledge to action cycle framework guides implementing research findings into clinical practice with stakeholder involvement.
Area of Science:
- Health Services Research
- Knowledge Translation Science
Background:
- A significant gap exists between healthcare research findings and their practical application by stakeholders.
- This evidence to practice gap hinders optimal patient care and health outcomes.
Purpose of the Study:
- To describe the knowledge to action cycle as a framework for effective knowledge translation.
- To highlight the integration of stakeholders and decision-makers throughout the research and implementation process.
Main Methods:
- The knowledge to action cycle framework is presented, detailing its phases from problem identification to sustained knowledge use.
- Emphasis is placed on the cyclical and iterative nature of knowledge translation, involving bidirectional communication.
Main Results:
- Knowledge creation involves synthesizing primary data into accessible knowledge products like guidelines and decision aids.
- Knowledge application encompasses adapting, implementing, monitoring, evaluating, and sustaining interventions with stakeholder input.
Conclusions:
- The knowledge to action cycle provides a structured approach to bridge the evidence to practice gap.
- Engaging healthcare decision-makers and stakeholders at all stages is crucial for successful knowledge translation and improved clinical practice.
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