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Updated: Nov 8, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Organophotocatalytic Aerobic Oxygenation of Phenols in a Visible-Light Continuous-Flow Photoreactor
Joël Wellauer1, Dragan Miladinov1, Thomas Buchholz1
1Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056, Basel, Switzerland.
Abstract:
A mild photocatalytic phenol oxygenation enabled by a continuous-flow photoreactor using visible light and pressurized air is described herein. Products for wide-ranging applications, including the synthesis of vitamins, were obtained in high yields by precisely controlling principal process parameters. The reactor design permits low organophotocatalyst loadings to generate singlet oxygen. It is anticipated that the efficient aerobic phenol oxygenation to benzoquinones and p-quinols contributes to sustainable synthesis.
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