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Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis
Jolene C Rudell1, Jérome Fleuriet2, Michael J Mustari3,4
1Department of Ophthalmology, University California San Diego, San Diego, California.
Journal of Binocular Vision and Ocular Motility
|April 19, 2021
Summary
Neurotrophins show promise for treating strabismus, a vision disorder. Local administration in animal models partially reversed strabismus, suggesting a new therapeutic avenue for eye alignment.
Area of Science:
- Ophthalmology
- Neuroscience
- Genetics
Background:
- Strabismus is a complex eye alignment disorder with genetic and neurophysiological roots.
- Ocular motor system plasticity and extraocular muscle tonus limit surgical strabismus treatment effectiveness.
- Neurotrophins are key factors in neuronal and muscle development, including extraocular muscles.
Purpose of the Study:
- To investigate the therapeutic potential of neurotrophins for strabismus.
- To explore sustained neurotrophin release as a method to enhance ocular motor system adaptation.
- To understand the complex effects of neurotrophins on extraocular muscle function.
Main Methods:
- Local administration of neurotrophins to extraocular muscles in an animal model of strabismus.
- Analysis of neurotrophin effects on muscle contraction, innervation, and precursor cell density.
Main Results:
- Partial reversal of strabismus observed in the animal model following neurotrophin administration.
- Demonstrated complexity of neurotrophin actions on extraocular muscle physiology.
- Identified potential for neurotrophic factors to modulate ocular motor system adaptation.
Conclusions:
- Neurotrophic factors represent a promising therapeutic strategy for strabismus.
- This approach may improve treatment outcomes and mitigate amblyopia and psychosocial effects.
- Further research into sustained neurotrophin delivery could optimize strabismus treatment.
Keywords:
Neurotrophic factorextraocular musclesglial derived neurotrophic factorinsulin-like growth factorstrabismusMore Related Videos
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