Related Experiment Video
Updated: Nov 8, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
CE: Multisystem Inflammatory Syndrome in Children: A Review
Kerry Shields1, Kristin Atlas, Jessica Strohm Farber
1Kerry Shields , Kristin Atlas , and Jessica Strohm Farber are pediatric critical care NPs at the Children's Hospital of Philadelphia (CHOP). Ruth Lebet is a nurse scientist at CHOP's Center for Pediatric Nursing Research and Evidence-Based Practice. Contact author: Kerry Shields, shieldsk@nursing.upenn.edu . The authors and planners have disclosed no potential conflicts of interest, financial or otherwise. A podcast with the authors is available at www.ajnonline.com .
Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition linked to COVID-19. This review covers MIS-C epidemiology, symptoms, diagnosis, and nursing care for children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic has affected children globally.
- While COVID-19 mortality is low in children, a serious multisystem inflammatory syndrome has emerged.
- This syndrome is recognized as multisystem inflammatory syndrome in children (MIS-C).
Purpose of the Study:
- To provide a comprehensive review of MIS-C.
- To detail the epidemiology, pathophysiology, and clinical presentation of MIS-C.
- To discuss diagnosis, treatment, patient education, and nursing implications for MIS-C.
Main Methods:
- This is a comprehensive literature review.
- Information was gathered on epidemiology, pathophysiology, clinical features, differential diagnoses, and treatments for MIS-C.
- Patient education, family guidance, and nursing roles were also reviewed.
Main Results:
- MIS-C is a post-infectious inflammatory condition associated with COVID-19.
- Key features include fever, rash, gastrointestinal symptoms, and cardiac involvement.
- Early recognition and supportive care are crucial for managing MIS-C.
Conclusions:
- MIS-C is a significant pediatric concern during the COVID-19 pandemic.
- Understanding MIS-C's diverse manifestations is vital for timely diagnosis and management.
- Nurses play a critical role in direct care, education, research, and public health initiatives related to MIS-C.
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Myocarditis II: Clinical Features and Diagnostic Tests
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

