Role of myeloid-derived suppressor cells in hormone-dependent cancers
Siddhartha Mukherjee1, Angela Rita Elia1, Arianna Calcinotto1
1Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona, Switzerland / Università della Svizzera Italiana (USI), Faculty of Biomedical Sciences, Lugano, Switzerland.
Abstract:
Tumour-infiltrating myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells. The main feature of MDSCs is their ability to suppress T-cell activation and function, which leads to immunosuppressive activity in the tumour microenvironment. Higher numbers of circulating and tumour-infiltrating MDSCs have been observed in a large number of patients with various types of tumour, and are linked to poor prognosis, especially in hormone-driven tumours. Recently, it has been demonstrated that the recruitment of MDSCs in prostate cancer confers resistance to canonical endocrine therapies, opening a new approach to the treatment of hormone-driven cancer patients.
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