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Systemic photoprotection in 2021.
T Searle1, F R Ali2, F Al-Niaimi3
1University of Birmingham Medical School, Birmingham, UK.
Clinical and Experimental Dermatology
|April 19, 2021
Summary
Systemic photoprotection supplements like carotenoids and flavonoids show limited evidence as standalone treatments. Nicotinamide may help reduce skin cancers as an add-on therapy, but more research is needed.
Area of Science:
- Dermatology
- Photobiology
- Nutritional Science
Background:
- Ultraviolet (UV) radiation causes DNA damage, necessitating photoprotection strategies.
- Systemic supplements are explored for UV protection, alone or with topical sunscreens.
- Keywords: carotenoids, flavonoids, systemic photoprotection, polyphenols, Polypodium leucotomos extract.
Purpose of the Study:
- To review the efficacy of systemic photoprotection supplements.
- To evaluate their potential as monotherapy or adjunctive treatments against UV damage.
Main Methods:
- Literature search of MEDLINE and EMBASE databases.
- Inclusion of English-language articles using specific keywords.
- Analysis of trial data for systemic photoprotection agents.
Main Results:
- Limited clinical trials support the use of carotenoids, flavonoids, and polyphenols as monotherapy for photoprotection.
- Nicotinamide demonstrated significant benefits in reducing nonmelanoma skin cancers.
- Evidence is insufficient to recommend these supplements as a replacement for sunscreen.
Conclusions:
- Current evidence does not support systemic supplements as a sole alternative to sunscreen.
- Nicotinamide shows promise as an adjunctive therapy for high-risk individuals.
- Further high-powered research comparing systemic therapies to topical photoprotection is essential.
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