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Systemic photoprotection in 2021.

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Systemic photoprotection supplements like carotenoids and flavonoids show limited evidence as standalone treatments. Nicotinamide may help reduce skin cancers as an add-on therapy, but more research is needed.

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Area of Science:

  • Dermatology
  • Photobiology
  • Nutritional Science

Background:

  • Ultraviolet (UV) radiation causes DNA damage, necessitating photoprotection strategies.
  • Systemic supplements are explored for UV protection, alone or with topical sunscreens.
  • Keywords: carotenoids, flavonoids, systemic photoprotection, polyphenols, Polypodium leucotomos extract.

Purpose of the Study:

  • To review the efficacy of systemic photoprotection supplements.
  • To evaluate their potential as monotherapy or adjunctive treatments against UV damage.

Main Methods:

  • Literature search of MEDLINE and EMBASE databases.
  • Inclusion of English-language articles using specific keywords.
  • Analysis of trial data for systemic photoprotection agents.

Main Results:

  • Limited clinical trials support the use of carotenoids, flavonoids, and polyphenols as monotherapy for photoprotection.
  • Nicotinamide demonstrated significant benefits in reducing nonmelanoma skin cancers.
  • Evidence is insufficient to recommend these supplements as a replacement for sunscreen.

Conclusions:

  • Current evidence does not support systemic supplements as a sole alternative to sunscreen.
  • Nicotinamide shows promise as an adjunctive therapy for high-risk individuals.
  • Further high-powered research comparing systemic therapies to topical photoprotection is essential.