Mitochondrial dynamics

Mitochondria cannot be created de novo but instead must arise from the fission (division) of a parental organelle. In addition to fission, mitochondria also fuse with one another and it is thought that a co-ordinated balance of these two processes controls mitochondrial shape, size and number. In the past 5-7 yr, molecular genetics coupled to state-of-the-art cell biology, in particular the use of mitochondrial-targeted green fluorescent protein (GFP), has enabled identification of proteins controlling mitochondrial shape, size and number in yeast and mammalian cells. Little is known about higher plant mitochondrial dynamics. Recently, however, several genes involved in the control of plant mitochondrial dynamics have been identified. The aim of this article is to bring together what is known about mitochondrial dynamics in any organisms and to relate this to our recent knowledge of the underlying processes in higher plants. Contents Summary 463 I. Introduction 464 II. Mitochondrial evolution 464 III. Mitochondria and the cytoskeleton 465 IV. Mitochondrial morphology, biogenesis, proliferation and inheritance 466 V. Mitochondrial fission and fusion 468 VI. Mitochondrial distribution 470 VII. Plant specific proteins playing a role in mitochondrial dynamics 470 VIII. Conclusions 471 Acknowledgements 475 References 475.