Primary central nervous system Hodgkin's lymphoma: a case report

Area of Science:

• Neurology
• Oncology
• Hematology

Background:

• Primary central nervous system Hodgkin's lymphoma (CNS-HL) is an exceptionally rare oncological diagnosis.
• Early diagnosis and prompt treatment are crucial for managing CNS-HL.

Observation:

• A 60-year-old male presented with lower extremity numbness and headache, indicative of a potential neurological issue.
• Diagnostic workup, including neuroimaging and biopsy after surgical intervention, confirmed primary CNS-HL.

Findings:

• The patient received a combination regimen of methotrexate, cytarabine, and sintilimab (an anti-PD-1 antibody).
• Intrathecal chemotherapy with cytarabine and dexamethasone was administered.
• Cranial magnetic resonance imaging revealed no residual lesion post-treatment, indicating complete remission.

Implications:

• This case highlights a successful treatment strategy for primary CNS-HL, a condition with limited therapeutic options.
• The combination of chemotherapy, immunotherapy, and intrathecal therapy offers a promising approach for managing this rare malignancy.
• Further research into optimal treatment protocols for CNS-HL is warranted based on this positive outcome.