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Updated: Nov 8, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Vascular endothelial damage in COPD: current functional assessment methods and future perspectives.

Marieta P Theodorakopoulou¹, Dimitra Rafailia Bakaloudi¹, Konstantina Dipla²

¹Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Expert Review of Respiratory Medicine

|April 20, 2021

Summary

Endothelial dysfunction is common in chronic obstructive pulmonary disease (COPD) and worsens with disease severity. Advanced methods can assess this vascular issue, aiding research into cardiovascular disease and COPD progression.

Keywords:

COPD NIRS endothelial dysfunction flow-mediated dilatation microvascular function

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Last Updated: Nov 8, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

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Published on: October 15, 2010

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

Cardiovascular Medicine
Pulmonology
Vascular Biology

Background:

Cardiovascular disease (CVD) is a leading cause of mortality in patients with chronic obstructive pulmonary disease (COPD).
Endothelial dysfunction is a key factor linking COPD severity, CVD, and poor outcomes.
Factors such as smoking, inflammation, and arterial stiffness contribute to this relationship.

Purpose of the Study:

To review functional methods for assessing endothelial damage in COPD patients.
To summarize evidence on the association between endothelial dysfunction and COPD comorbidities/outcomes.
To highlight the role of endothelial dysfunction in the progression of both COPD and CVD.

Main Methods:

A narrative review of studies published in PubMed and Scopus up to November 25, 2020.
Inclusion of both invasive (e.g., coronary angiography) and non-invasive (e.g., Flow-Mediated Dilatation, Peripheral Arterial Tonometry, Near-Infrared Spectroscopy) functional assessment methods.
Synthesis of existing evidence on endothelial function assessment in COPD.

Main Results:

Endothelial dysfunction is present in early stages of COPD and exacerbates with disease progression and acute exacerbations.
Various functional methods, from invasive to non-invasive, are available for evaluating endothelial function.
These methods have significantly advanced clinical research in understanding vascular health in COPD.

Conclusions:

Endothelial dysfunction is an early and progressive feature of COPD, closely linked to disease severity and cardiovascular risk.
Novel functional assessment methods provide detailed, real-time insights into vascular parameters.
Increased utilization of these advanced techniques is recommended to elucidate the impact of endothelial damage on cardiovascular health and COPD progression.