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Related Experiment Video

Updated: Nov 8, 2025

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Three-dimensional Printing-Driving Liver Therapies.

Xiaohong Li¹, Liang Wen¹, Jiao Liu¹

¹Center of 3D Printing & Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.

Current Medicinal Chemistry

|April 20, 2021

Summary

Three-dimensional (3D) bioprinting offers a promising solution for end-stage liver diseases, addressing donor shortages and transplantation limitations. Advanced bioinks and bioprinters are key to creating functional bioartificial livers for widespread clinical use.

Keywords:

3D bioprinting biliary networks.bioartificial livers bioinks bioprinters vascularized and innervated tissues

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Last Updated: Nov 8, 2025

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In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

Area of Science:

Regenerative Medicine
Biotechnology
Medical Engineering

Background:

End-stage liver diseases pose significant health challenges with limited effective treatments.
Allogeneic organ transplantation is a viable option but faces donor scarcity, immune rejection, and high costs.
Three-dimensional (3D) bioprinting, integrated with medical imaging, is emerging as a transformative approach for liver therapies.

Purpose of the Study:

To review advancements in bioinks and bioprinters for vascularized and innervated liver tissue 3D bioprinting.
To emphasize the incorporation of biliary networks in bioartificial liver development.
To discuss the potential of 3D bioprinting for mass and personalized production of bioartificial livers.

Main Methods:

Review of current literature on 3D bioprinting technologies for liver tissue engineering.
Analysis of essential components: bioinks, bioprinters, and imaging techniques (MRI, CT).
Focus on strategies for creating vascularized, innervated, and functional liver constructs.

Main Results:

Identification of critical requirements for successful liver 3D bioprinting, from data acquisition to clinical application.
Highlighting advanced bioinks and bioprinters enabling the creation of complex liver structures.
Emphasis on the progress and challenges in incorporating vascular and neural networks.

Conclusions:

3D bioprinting holds immense potential to overcome limitations of current liver disease treatments.
Solving current technical challenges will enable the mass and personalized production of bioartificial livers.
This technology promises to revolutionize the treatment landscape for end-stage liver diseases.