Related Experiment Video
Updated: Nov 8, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Developmental Enamel Defects and Dental Caries in the Primary Dentition of Preterm Children
Elisa Feuser1, Natália Moreira Teixeira2, Poliana Valdelice Cruz3
1Dr. Feuser is a graduate student, Department of Pediatric Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Insights
Preterm (PT) and/or low birth weight (LBW) children exhibit more developmental enamel defects (DED) than full term (FT) infants. Neonatal intensive care unit admission is linked to DED, but dental caries rates are similar between groups.
Area of Science:
- Pediatric Dentistry
- Neonatal Health
- Developmental Biology
Background:
- Developmental enamel defects (DED) can impact oral health in children.
- Preterm birth and low birth weight are associated with various health challenges.
- Understanding DED prevalence in these groups is crucial for early intervention.
Purpose of the Study:
- To compare DED and dental caries in preterm/low birth weight (PT/LBW) versus full term/normal birth weight (FT/NBW) children.
- To investigate associations between DED and socioeconomic, gestational, and postnatal factors.
Main Methods:
- Study included 84 children aged 2-5 years, matched for sex and age (1:1 ratio).
- Groups comprised 42 PT/LBW children and 42 FT/NBW children.
- Data analyzed using descriptive statistics, bivariate analysis, and Poisson regression.
Main Results:
- PT/LBW children had significantly more teeth with DED compared to FT/NBW children.
- No significant difference in dental caries prevalence was found between the groups.
- Admission to the neonatal intensive care unit was significantly associated with DED (PR=0.21).
Conclusions:
- PT/LBW children demonstrate a higher incidence of DED.
- Dental caries rates do not differ significantly between PT/LBW and FT/NBW children.
- Neonatal intensive care unit admission is a risk factor associated with DED in early childhood.
Abstract:
Purpose: To assess developmental enamel defects (DED) and dental caries of preterm (PT) and/or low birth weight (LBW) children compared to full term (FT) and/or normal birth weight (NBW) infants, and to evaluate the association of DED with socioeconomic factors, gestational health, and postnatal factors.
Methods: This study included 84 two- to five-year-old children. The PT/LBW group included 42 children who received medical care at a university hospital, while FT/ NBW group included 42 subjects. Children were matched by sex and age (1:1 ratio). Descriptive statistics, bivariate analysis, and Poisson regression were used to analyse the data.
Results: Children in the PT/LBW group had a significantly higher number of teeth with DED than subjects in the FT/NBW group. No difference was observed between the groups regarding dental caries (P >0.05). Admission to the neonatal intensive care was significantly associated with DED unit (prevalence ratio = 0.21 [95 percent confidence interval = 0.1 to 0.5]).
Conclusion: PT/LBW children presented more DED than FT/NBW children. No differences were observed between the groups for dental caries. Admission to the neonatal intensive care unit was associated with DED.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
Teratogenicity
Neurulation
Inborn Errors of Metabolism

