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Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Updated: Nov 8, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Integrated computer-aided engineering and design for DNA assemblies.

Chao-Min Huang¹, Anjelica Kucinic², Joshua A Johnson³

¹Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA.

Nature Materials

|April 20, 2021

Summary

This summary is machine-generated.

Researchers developed a new design pipeline for DNA nanodevices, enabling better control over mechanical and dynamic properties. This computational approach allows for the creation of complex, functional DNA assemblies with improved performance.

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Last Updated: Nov 8, 2025

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Published on: December 1, 2017

Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Published on: August 15, 2018

Designing a Bio-responsive Robot from DNA Origami

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Published on: July 8, 2013

Area of Science:

Nanotechnology
Biophysics
Synthetic Biology

Background:

DNA nanodevices are utilized in diverse fields like medicine and biosensing.
Current designs primarily focus on geometry, limiting functional property control (e.g., force response).

Purpose of the Study:

To introduce an iterative design pipeline for DNA assemblies.
To enable rational design of mechanical and dynamical properties in DNA nanostructures.

Main Methods:

Integration of computer-aided engineering with coarse-grained molecular dynamics.
A computer-aided design approach combining top-down automation and bottom-up geometric control.

Main Results:

Facilitated rapid construction of large, multicomponent DNA assemblies from 3D models.
Achieved finer control over geometrical, mechanical, and dynamical properties of DNA structures.
Expanded the scope of structural complexity and enhanced design capabilities for DNA assemblies.

Conclusions:

The developed framework allows for automated, precise design of functional DNA nanodevices.
This approach enhances the predictability and performance of DNA-based nanostructures.
Enables the creation of more sophisticated and versatile DNA nanodevices for various applications.