An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated...

Area of Science:

• * Molecular Biology
• * Pathology
• * Virology

Background:

• * Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic with no specific treatments.
• * COVID-19 is increasingly linked to thrombosis and coagulopathy.
• * The molecular mechanisms underlying COVID-19-associated thrombosis are not fully understood.

Purpose of the Study:

• * To review the hypothetical crosstalk between distinct signaling pathways contributing to thrombotic events in COVID-19.
• * To explore potential molecular mechanisms driving thrombosis in SARS-CoV-2 infection.
• * To identify promising therapeutic targets for COVID-19.

Main Methods:

• * Literature review of existing studies on COVID-19, thrombosis, and related signaling pathways.
• * Analysis of hypothetical interactions between apoptosis, inflammation, hypoxia, and angiogenesis.
• * Synthesis of current knowledge to propose mechanistic links to thrombotic events.

Main Results:

• * Hypothesized crosstalk between apoptosis, inflammation, hypoxia, and angiogenesis pathways in SARS-CoV-2 infection.
• * These pathways may collectively contribute to the activation of the coagulation cascade.
• * Potential molecular mechanisms for COVID-19-associated thrombosis are elucidated.

Conclusions:

• * Understanding the interplay of these signaling pathways is crucial for unraveling COVID-19 pathogenesis.
• * The identified pathways represent potential targets for novel therapeutic interventions.
• * Further research is warranted to validate these hypothetical mechanisms and therapeutic strategies.