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Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center

Feng Gao1, Jiajian Wang1, Junyi Chen1

  • 1Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|April 20, 2021
PubMed

Insights

This study identified the causes of angle-closure glaucoma (ACG) in young Chinese patients under 40. Primary angle-closure glaucoma, uveitis, and anterior segment dysgenesis were common, highlighting the need for early detection in young individuals.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Pediatric Ophthalmology

Background:

  • Angle-closure glaucoma (ACG) is less common in young individuals.
  • Understanding the specific etiologies in younger populations is crucial for effective management.
  • Chinese populations may present unique epidemiological characteristics for ACG.

Purpose of the Study:

  • To investigate the causes and clinical features of angle-closure glaucoma (ACG) in patients under 40 years old in China.
  • To identify the most frequent etiologies contributing to ACG in this specific demographic.
  • To characterize the clinical presentation of ACG in young Chinese patients.

Main Methods:

  • Retrospective case series analysis of inpatients diagnosed with ACG.
  • Inclusion criteria: age ≤ 40 years, admitted between 2002-2017.
  • Comprehensive review of medical charts to determine underlying causes and clinical features.

Main Results:

  • 298 patients (463 eyes) were analyzed; mean age 25.6 years.
  • Top etiologies: Primary angle-closure glaucoma (PACG) (32.6%), uveitis (20.3%), and anterior segment dysgenesis (ASD) (15.1%).
  • ASD was the leading cause in patients <20 years; PACG predominantly occurred after age 30.

Conclusions:

  • ACG in young Chinese patients presents with diverse etiologies, though often identifiable.
  • Anterior segment dysgenesis is a significant cause of ACG in very young patients (<20 years).
  • Thorough ophthalmic examinations are essential for early diagnosis and treatment of ACG in young individuals.
Abstract

Keywords:
Angle-closure glaucomaChineseEtiologiesYoung patients

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