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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Cerebral aspergillosis

Laura Frascheri, Birger Breivik, Rita Helleren

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |April 20, 2021
    PubMed
    Abstract

    Insights

    Diagnosing fungal brain abscesses is challenging. This case highlights successful treatment of a non-fumigatus Aspergillus brain abscess in an immunocompromised patient, emphasizing MRI

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Radiology

    Background:

    • Intracerebral fungal abscesses present diagnostic challenges due to limited lab tests and overlapping imaging features with other lesions.
    • Distinguishing fungal from pyogenic brain abscesses is crucial for timely and effective treatment.

    Observation:

    • A case of a middle-aged immunocompromised woman initially diagnosed with bacterial meningitis.
    • Magnetic Resonance Imaging (MRI) revealed findings suggestive of fungal abscesses.
    • Lumbar puncture confirmed non-fumigatus Aspergillus via PCR.

    Findings:

    • The patient received targeted antifungal therapy.
    • Demonstrated positive clinical, biochemical, and radiological response to treatment.
    • Serial MRI scans showed progressive resolution of abscesses over 12 weeks.

    Implications:

    • Early consideration of Central Nervous System (CNS) fungal infections is vital in immunocompromised patients presenting with neurological symptoms.
    • MRI is instrumental in differentiating fungal from pyogenic brain abscesses.
    • Prompt diagnosis and appropriate antifungal treatment lead to favorable outcomes in fungal brain abscesses.

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