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Eliminating non-healing wounds: a review
1Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico 00901, USA.
Abstract:
Non-healing cutaneous wounds, including pressure, diabetic and venous ulcers, are wounds where the skin and underlying tissues die due to ischemia, infection, metabolic conditions, immunosuppression or radiation. Some can be eliminated with relatively straightforward techniques, although they may continue to grow in diameter and depth, becoming increasingly painful and never heal. Others respond more slowly or poorly to treatment, while others are recalcitrant to treatments. This review examines the etiology of non-healing wounds and different wound management treatments. In addition, it examines the efficacy of platelet-rich plasma in promoting wound healing and its potential mechanisms of action. It is concluded that platelet-rich plasma alone, but more effectively when combined with another technique(s), has the greatest potential for promoting complete wound healing. However, further studies are required to determine whether the efficacy of wound healing induced by each of these techniques is enhanced by applying the techniques simultaneously.
Insights
Non-healing wounds like diabetic ulcers require advanced treatments. Platelet-rich plasma shows promise, especially when combined with other therapies, for promoting complete wound healing.
Area of Science:
- Dermatology and Regenerative Medicine
- Wound Healing Research
Background:
- Non-healing cutaneous wounds, including pressure, diabetic, and venous ulcers, result from tissue death due to ischemia, infection, metabolic issues, or immunosuppression.
- These chronic wounds often become painful, increase in size, and are resistant to conventional treatments.
Purpose of the Study:
- To review the causes (etiology) of non-healing wounds.
- To examine various wound management strategies.
- To evaluate the effectiveness and mechanisms of platelet-rich plasma (PRP) in promoting wound healing.
Main Methods:
- Literature review focusing on the etiology of non-healing wounds.
- Analysis of different wound management techniques.
- Examination of studies on platelet-rich plasma efficacy and mechanisms in wound healing.
Main Results:
- Platelet-rich plasma (PRP) demonstrates significant potential in promoting wound healing.
- PRP is more effective when used in conjunction with other therapeutic techniques.
- Further research is needed to confirm synergistic effects of simultaneous combined therapies.
Conclusions:
- Platelet-rich plasma is a promising therapeutic agent for non-healing cutaneous wounds.
- Combination therapies involving PRP may offer superior outcomes compared to PRP alone.
- Investigating simultaneous application of combined techniques is crucial for optimizing wound healing.
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