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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
434
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

378
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
378
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

683
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
683
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

556
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
556
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

398
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
398
Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

1.2K
The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
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Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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[Slow transit constipation].

Marco Sailer1

  • 1Klinik für Chirurgie, Agaplesion Bethesda Krankenhaus Bergedorf, Glindersweg 80, 21029, Hamburg, Deutschland. sailer@bkb.info.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|April 20, 2021
PubMed
Summary
This summary is machine-generated.

Slow transit constipation (STC), a rare condition in middle-aged women, requires excluding other causes and physiological testing. Conservative treatment is primary, with surgery like subtotal colectomy offering over 80% success for persistent cases.

Keywords:
ColectomyColonic transit timeConservative treatment optionsGastrointestinal functional analysesIdiopathic constipation

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High-throughput Measurement of Gut Transit Time Using Larval Zebrafish
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Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
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Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Slow transit constipation (STC) is a rare condition predominantly affecting middle-aged women.
  • Its pathophysiology and etiology are not well understood, suggesting a multifactorial pathogenesis.

Purpose of the Study:

  • To outline the diagnostic and therapeutic approach for slow transit constipation.
  • To emphasize the importance of excluding differential diagnoses and performing physiological investigations.

Main Methods:

  • Differential diagnosis involves excluding mechanical, drug-induced, degenerative, metabolic, endocrine, neurologic, and psychiatric causes.
  • Gastrointestinal physiological investigations, including colonic transit studies, are mandatory.
  • Exclusion of pangastrointestinal delay, pelvic floor dysfunction, and irritable bowel syndrome is necessary.

Main Results:

  • Conservative management is the initial treatment of choice.
  • Subtotal colectomy with ileorectal anastomosis is the standard surgical procedure for STC.
  • With strict patient selection, surgical success rates exceed 80%.

Conclusions:

  • STC necessitates an interdisciplinary approach for diagnosis and management.
  • While conservative measures are preferred initially, surgical intervention can be highly effective for refractory cases.