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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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The ABO Blood Group01:12

The ABO Blood Group

3.6K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Updated: Nov 8, 2025

Cecal Ligation Puncture Procedure
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ABO blood types and sepsis mortality.

Theis S Itenov1,2, Daniel I Sessler3, Ashish K Khanna4,5

  • 1CHIP / PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, The Capital Region of Denmark, Denmark. Theis.skovsgaard.itenov@regionh.dk.

Annals of Intensive Care
|April 20, 2021
PubMed
Summary

Patients with blood type B had a slightly lower risk of 30-day mortality and less endothelial damage during sepsis. This finding relates to ABO blood groups and sepsis outcomes.

Keywords:
AnaesthesiaBlood typeIntensive careMortalitySepsisSeptic shock

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Area of Science:

  • Critical Care Medicine
  • Hematology
  • Immunology

Background:

  • Sepsis is a life-threatening condition associated with high mortality and organ dysfunction.
  • ABO blood types are known to influence various physiological processes and disease susceptibilities.
  • The relationship between ABO blood types and sepsis outcomes, including mortality, acute kidney injury (AKI), and endothelial damage, requires further investigation.

Purpose of the Study:

  • To investigate the association between ABO blood types and 30-day mortality in critically ill patients with sepsis.
  • To determine if ABO blood types influence the risk of developing acute kidney injury (AKI) in sepsis.
  • To assess the impact of ABO blood types on endothelial damage markers in septic patients.

Main Methods:

  • Retrospective cohort study including three independent cohorts of adult patients with septic shock.
  • Pooled meta-analysis to compare 30-day mortality across different ABO blood types.
  • Measurement of endothelial damage using soluble thrombomodulin and syndecan-1 concentrations.

Main Results:

  • A total of 12,342 patients with severe sepsis were included in the analysis.
  • Blood type B was associated with a slightly lower risk of 30-day all-cause mortality (adjusted HR 0.88; 95% CI 0.79-0.98).
  • No significant difference in AKI risk was observed across blood types. Lower levels of soluble thrombomodulin and syndecan-1 were found in blood types B and O compared to A, indicating reduced endothelial damage.

Conclusions:

  • Septic patients with blood type B exhibited less endothelial damage and a modest reduction in mortality.
  • The findings suggest a potential role for ABO blood groups in modulating sepsis severity and outcomes.
  • While the association is noted, ABO blood type is an unmodifiable factor.