Association of Plasma Connective Tissue Growth Factor Levels with Hyperthyroid Heart Disease

Area of Science:

• Cardiology
• Endocrinology
• Biomarkers

Background:

• Hyperthyroid heart disease (HHD) is a severe complication of overt hyperthyroidism, increasing mortality risk.
• Early identification of patients at high risk for HHD is crucial for improved clinical outcomes.
• Connective tissue growth factor (CTGF) is implicated in cardiac remodeling and dysfunction.

Purpose of the Study:

• To investigate the association between plasma CTGF levels and the risk of developing HHD.
• To determine if CTGF can serve as a predictive biomarker for HHD.

Main Methods:

• A study included 142 overt hyperthyroid patients without HHD and 99 patients with HHD.
• Plasma CTGF levels were measured using ELISA kits.
• Clinical data and echocardiography parameters were analyzed, including logistic regression.

Main Results:

• Plasma CTGF levels were significantly higher in patients with HHD compared to those without (P=0.002).
• CTGF levels correlated positively with thyroid hormones, antibodies, cardiac enzymes, and cardiac chamber dimensions.
• Elevated CTGF levels (quartiles 3 and 4) were associated with increased HHD risk, with quartile 4 being an independent risk factor after adjustment.

Conclusions:

• Patients with HHD exhibit elevated plasma CTGF levels.
• CTGF is identified as an independent risk factor for HHD.
• Plasma CTGF levels show potential as a predictive biomarker for HHD risk.