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Prognostic analysis of Behçet's disease with aortic regurgitation or involvement

X Li1,2,3,4, X Wen5, J Xu1,2,3,4

  • 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
|April 20, 2021
PubMed

Insights

Immunosuppressive therapy (IST) significantly improves outcomes for Behçet

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Immunology

Background:

  • Aortic regurgitation is a common cardiovascular complication in Behçet's disease (BD).
  • BD patients with aortic involvement often face misdiagnosis and poor prognosis.
  • Surgical outcomes for these patients can be suboptimal, necessitating further investigation into prognostic factors.

Purpose of the Study:

  • To analyze factors influencing the prognosis of Behçet's disease patients with aortic regurgitation and/or aortic involvement.
  • To compare diagnostic criteria for Behçet's disease in this patient cohort.
  • To evaluate the impact of surgical interventions and immunosuppressive therapy (IST) on patient outcomes.

Main Methods:

  • Retrospective analysis of 22 patients with BD and aortic involvement (2012-2017).
  • Evaluation of Behçet's disease diagnosis using two sets of international criteria.
  • Assessment of the effects of surgical treatment and IST on prognosis, including reoperation and mortality rates.

Main Results:

  • The International Criteria for Behçet's Disease showed higher diagnostic utility than the International Study Group criteria.
  • Surgical interventions (aortic valve/root replacement) did not significantly impact survival or reoperation rates.
  • Immunosuppressive therapy (IST) significantly reduced the incidence of reoperation and death in BD patients with aortic disease.

Conclusions:

  • Immunosuppressive therapy (IST) is a critical factor in improving the prognosis for Behçet's disease patients experiencing aortic regurgitation and/or aortic involvement.
  • IST significantly reduces adverse events such as reoperation and death in this vulnerable patient population.
Abstract

Keywords:
Aortic involvementAortic regurgitationBehçet’s diseaseDiagnosisPrognosis

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