Ehrlichia-induced hemophagocytic lymphohistiocytosis after autologous stem cell transplant

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Angel A Mitma1, Mary J Burgess2, Frits van Rhee3

  • 1Department of Internal Medicine, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|April 20, 2021
PubMed

Hemophagocytic lymphohistiocytosis (HLH) causes multiorgan failure due to the release of multiple cytokines mediating widespread inflammation. We present a patient with multiple myeloma on maintenance chemotherapy with the anti-CD38 monoclonal antibody daratumumab after autologous stem cell transplant (ASCT) who developed fatal HLH secondary to Ehrlichiosis.

Keywords:
Ehrlichiahemophagocytic lymphohistiocytosis (HLH)multiorgan failuremultiple myelomastem cell transplant

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