Risk factors of contrast-induced nephropathy after percutaneous coronary intervention: a retrospective analysis
Jing Wang1, Chunyu Zhang2, Zhina Liu1
1Department of Cardiology, Yan'an University Affiliated Hospital, Yan'an, China.
Insights
Contrast-induced nephropathy (CIN) is a significant risk following percutaneous coronary intervention (PCI). Key risk factors include reduced ejection fraction, elevated creatinine, older age, and high N-terminal pro-B-type natriuretic peptide levels.
Area of Science:
- Cardiology
- Nephrology
- Interventional Cardiology
Background:
- Contrast-induced nephropathy (CIN) is a serious complication.
- It frequently affects patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
Purpose of the Study:
- To identify and analyze independent risk factors for CIN in patients undergoing PCI.
- Understanding these factors is crucial for early prevention strategies.
Main Methods:
- Retrospective analysis of 1331 patients with ACS who underwent PCI between January 2017 and January 2020.
- Collected and compared patient characteristics and medical information.
Main Results:
- The incidence of CIN was 15.33%.
- Independent risk factors identified include: left ventricular ejection fraction ≤45%, serum creatinine levels ≤60 μmol/L, age ≥65 years, log N-terminal pro-B-type natriuretic peptide levels ≥2.5 pg/mL, uric acid levels ≥350 μmol/L, and triglyceride levels ≤1.30 mmol/L.
- Emergency PCI was also noted as a potential risk factor.
Conclusions:
- CIN poses a significant risk in patients undergoing PCI.
- Early identification and prevention are essential for patients with identified risk factors to reduce CIN occurrence.
Objective:
Contrast-induced nephropathy (CIN) is a serious complication in patients with acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). This study aimed to analyze the potential risk factors for CIN in patients undergoing PCI.
Methods:
Patients with ACS who underwent PCI treatment from January 2017 to January 2020 were selected. The patients' characteristics and medical information were collected and compared.
Results:
A total of 1331 patients undergoing PCI were included. The incidence of CIN was 15.33%. Logistic regression analyses showed that a left ventricular ejection fraction ≤45% (odds ratio [OR] 4.18, 95% confidence interval [CI] 1.10-7.36), serum creatinine levels ≤60 μmol/L (OR 3.03, 95% CI 1.21-5.57), age ≥65 years (OR 2.75, 95% CI 1.32-4.60), log N-terminal pro-B-type natriuretic peptide levels ≥2.5 pg/mL (OR 2.31, 95% CI 1.18-5.13), uric acid levels ≥350 μmol/L (OR 2.29, 95% CI 1.04-5.30), emergency percutaneous intervention (OR 1.35, 95% CI 0.34-3.12), and triglyceride levels ≤1.30 mmol/L (OR 1.10, 95% CI 0.01-2.27) were independent risk factors for CIN in patients who underwent PCI.
Conclusions:
Early prevention is required to reduce the occurrence of CIN in patients who undergo PCI and have risk factors for CIN.
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