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Updated: Nov 8, 2025

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Published on: May 23, 2025
Delayed bowel perforation after instilling over warmed peritoneal dialysate
Xueli Lai1, Mingming Nie2, Xiaodong Xu3
1Department of Nephrology, Shanghai Changhai Hospital, 168 Changhai Road, Shanghai, 200433, P.R. China.
Hot dialysis solution caused delayed bowel perforation in a peritoneal dialysis patient, leading to fatal septic shock. Strict adherence to standardized procedures is crucial for patient safety in home-based renal replacement therapy.
Area of Science:
- Nephrology
- Gastroenterology
- Medical Safety
Background:
- Peritoneal dialysis (PD) is a common home-based treatment for end-stage renal disease (ESRD).
- While generally safe, complications can arise from improper procedure execution.
- Direct thermal organ damage during PD is considered rare.
Observation:
- A case of a peritoneal dialysis patient experiencing severe abdominal pain and feculent effluent is presented.
- Symptoms emerged three weeks after the patient instilled heated dialysis solution.
- The patient's condition rapidly deteriorated, leading to septic shock despite emergency surgical intervention.
Findings:
- Autopsy and biopsy revealed intestinal necrosis and perforation.
- The findings indicate delayed bowel perforation as a direct consequence of using excessively hot dialysis fluid.
- This rare complication underscores the potential for severe thermal injury.
Implications:
- This case highlights the critical importance of standardized protocols and meticulous technique in home peritoneal dialysis.
- Healthcare providers must emphasize the risks associated with improper fluid temperature management.
- Ensuring patient education and adherence to safety guidelines is paramount to prevent such devastating outcomes.
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