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Persistent luminescence nanoparticles for cancer theranostics application.

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Summary

Persistent luminescence nanoparticles (PLNPs) offer advanced, autofluorescence-free tumor imaging with deep penetration. These versatile materials also enable combined diagnostic and therapeutic applications for cancer treatment.

Keywords:
Multiple excitation sourcesPersL imagingPersistent luminescence nanoparticlesSurface modificationSynthesisTheranostics

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Oncology

Background:

  • Persistent luminescence nanoparticles (PLNPs) are advanced optical materials emitting light after excitation cessation.
  • PLNPs offer unique advantages for in vivo tumor imaging, including high sensitivity and deep tissue penetration.
  • Their ability to be functionalized enables combined imaging and therapeutic applications.

Purpose of the Study:

  • To review recent advancements in PLNPs for biomedical applications, focusing on cancer.
  • To discuss synthesis, functionalization, and toxicity of PLNPs.
  • To highlight PLNPs' utility in persistent luminescence (PersL) imaging and theranostics.

Main Methods:

  • Summarized recent developments in PLNPs synthesis and surface functionalization.
  • Reviewed toxicity studies of PLNPs.
  • Discussed in vivo PersL imaging and multimodal imaging strategies using various excitation sources.

Main Results:

  • PLNPs demonstrate significant potential for autofluorescence-free, high-sensitivity in vivo tumor imaging.
  • PLNPs facilitate multimodal imaging through diverse excitation sources (UV, LED, NIR, X-ray, radiopharmaceuticals).
  • PLNPs are effective in cancer theranostics, including guided surgery, photothermal/photodynamic therapy, and drug delivery.

Conclusions:

  • PLNPs are highly promising for advanced cancer imaging and theranostics.
  • Further research into PLNPs' translational applications in medicine is warranted.
  • Challenges and future prospects for PLNPs in translational medicine were discussed.