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Updated: Nov 8, 2025

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Post-anesthesia care unit desaturation in adult deep extubation patients
Jeremy Juang1,2, Martha Cordoba3,4, Mark Xiao3,4
1Department of Anesthesiology, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA. jeremy_juang@meei.harvard.edu.
Objective:
Deep extubation refers to endotracheal extubation performed while a patient is deeply anesthetized and without airway reflexes. After deep extubation, patients are sent to the post-anesthesia care unit (PACU) to recover, an area with notably different management and staffing than the operating room (OR). One of the most frequent and concerning complications to occur in the PACU is hypoxemia. As such, this study seeks to evaluate the incidence of desaturation, defined by SpO2 < 90% for longer than 10 s, in the PACU following deep extubation. Additionally, we hope to assess the consequence of desaturation on perioperative workflow by comparing PACU recovery times.
Results:
Following deep extubation, 4.3% of patients (13/300) experienced desaturation in the PACU. Every episode was notably minor, with patients reverting to normal saturation levels within a minute. Of the 26 case factors assessed, 24 had no significant association desaturation in the PACU, including the amount of time spent in the PACU. History of asthma was the only statistically significant factor found to be positively associated with desaturation. We find that PACU desaturation episodes following deep extubation are rare. Our findings suggest that deep extubation is a viable and safe option for patients without significant respiratory tract pathology.
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