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Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children

Kuan-Wen Su1, Chih-Yung Chiu2, Ming-Han Tsai3

  • 1Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|April 21, 2021
PubMed

Insights

Cord blood soluble Fas ligand (FasL) levels predict long-term allergic rhinitis and airway obstruction in children. Higher cord blood FasL is linked to allergic rhinitis and reduced lung function by age seven.

Area of Science:

  • Pediatric Allergy and Immunology
  • Immunology
  • Pulmonology

Background:

  • Serum or cord blood soluble Fas ligand (FasL) has been linked to asthma and other allergic conditions in short-term studies.
  • The association between cord blood FasL and long-term allergic outcomes in children remains under-investigated.

Purpose of the Study:

  • To investigate the association between cord blood soluble Fas ligand (FasL) levels and allergic outcomes at age seven.
  • To determine if cord blood FasL can serve as a predictor for childhood allergic diseases.

Main Methods:

  • The Prediction of Allergies in Taiwanese Children birth cohort study enrolled healthy newborns.
  • Cord blood samples were collected at birth to measure soluble Fas ligand (FasL) levels.
  • At age seven, children underwent diagnosis for allergic outcomes, including specific immunoglobulin E, fractional exhaled nitric oxide (FeNO), and pulmonary function tests.

Main Results:

  • Elevated cord blood soluble FasL levels were significantly associated with allergic rhinitis (OR=2.41, p=0.012) and expiratory airway obstruction (OR=2.11, p=0.022) at age seven.
  • Cord blood soluble FasL levels showed a positive correlation with fractional exhaled nitric oxide (FeNO) (p=0.006) and Dermatophagoides pteronyssinus-specific immunoglobulin E (p=0.02).

Conclusions:

  • Cord blood soluble Fas ligand (FasL) levels are associated with allergic rhinitis, obstructive lung function, FeNO levels, and house dust mite sensitization in seven-year-old children.
  • Cord blood soluble FasL may serve as a valuable predictive biomarker for identifying children at risk of developing allergic diseases.
Abstract

Keywords:
Allergic rhinitisBirth cohort studyLung function testsSoluble Fas ligandUmbilical cord blood

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