Effect of different level of resistant starch in induce diabetic rats

The objective of this study to evaluate the effect of Resistant Starch (RS) on lipid profile, blood glucose, hormones and TNF-α in Type 2 Diabetes (T2DM). 45 Wister male rats were divided into 5 groups each having 9 rats: without T2DM negative control (NC) with T2DM positive control (PC), resistant starch: 0.20g/kg body weight (HM_0.20), resistant starch: 0.30g/kg body weight (HM_0.30) and resistant starch: 0.40g/kg body weight (HM_0.40). Different levels were added in basal diets while negative and positive control received basal diet. Animals fed on different diets were induced type 2 diabetes 60mg/kg streptozotocin solution injected intraperitoneally in rats. Results of blood glucose showed significantly (P<0.05) lower in all rats fed HM_0.20, HM_0.30 and HM_0.40. In case of lipid profile results indicated that HM0.04 showed significant (P<0.05) increase in HDL level while cholesterol, LDL, triglycerides were reduced. After treatment hormonal profile, leptin, insulin and TNF-α level were significantly (P<0.05) reduced. It may be concluded that RS is the new approach to treat the T2DM.