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Differences in microbiota between acute and chronic perianal eczema.
Ming Ma1, Hongmei Lu1, Zuozhen Yang2,3
1Department of Dermatology, Beijing Coloproctological Hospital, Beijing Erlonglu Hospital, Beijing.
Medicine
|April 21, 2021
Summary
The perianal microbiota of acute perianal eczema (APE) patients shows a higher Staphylococcus content compared to chronic perianal eczema (CPE). This study highlights differences in skin microbiome composition between APE and CPE.
Area of Science:
- Microbiology
- Dermatology
- Human Microbiome
Background:
- The role of microbiota in cutaneous diseases is increasingly recognized.
- Perianal eczema is a common condition, but its associated microbiota remains underexplored.
- Understanding the perianal microbiome may offer insights into disease pathogenesis.
Purpose of the Study:
- To profile the perianal microbiota in patients with perianal eczema.
- To investigate potential differences in microbiota composition between acute perianal eczema (APE) and chronic perianal eczema (CPE).
Main Methods:
- 16S rRNA gene sequencing (V4 region) was performed on perianal samples.
- Microbiota profiling was conducted on 101 APE patients and 156 CPE patients.
- Analysis included microbial alpha-diversity and community structure.
Main Results:
- Microbial alpha-diversity and structure were similar between APE and CPE groups.
- APE patients exhibited significantly higher Staphylococcus abundance (22.2%) compared to CPE patients (P < .01).
- Genera like Prevotella, Streptococcus, and Bifidobacterium showed an upward trend in APE, though not statistically significant.
Conclusions:
- The perianal microbiota of APE patients is characterized by an enrichment of Staphylococcus compared to CPE patients.
- These findings contribute to understanding the microbial landscape of perianal eczema.
- Further research is warranted to elucidate the clinical implications of these microbial differences.
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